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KMID : 0861020070220020175
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Korea Journal of Herbology
2007 Volume.22 No. 2 p.175 ~ p.180
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Effects of Samso-Eum on cytokine productions in asthmatic mice
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Kim Hyung-Woo
Cho Soo-Jin
Kim Bu-Yeo
Back Jin-Woong
Jung Hyun-Woo
Cho Su-In
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Abstract
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Objective : The application of Sam So Eum (蔘蘇飮, SSE) as a herbal medicine to treat asthma in mice has been studied and the mechanism of cytokine production in asthmatic mice was discussed. Recently, SSE was known to have anti-allergic activity. However, its therapeutic mechanisms are unclear.
Methods : So, we investigated the effects of SSE on levels of several cytokines in bronchoalveolar lavage fluid (BALF) using flow cytometric analysis in allergen-induced asthma.
Results : In this experiment, SSE decreased levels of IL-la, IL-17 and GM-CSF respectively. Contrary, SSE restored level of IFN-g toward naive level in BALF.
Conclusion : In conclusion, we demonstrate that SSE is useful to treat asthma and it’s therapeutic mechanisms are involved in Thl skewing reaction.
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KEYWORD
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Samso-Eum, IL-la, IL-17, GM-CSF, IFN-g, Asthma
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